Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver.

Autor:in

Wang, Ying; Wimmer, Ursula; Lichtlen, Peter; Inderbitzin, Daniel; Stieger, Bruno; Meier, Peter J; Hunziker, Lukas; Stallmach, Thomas; Forrer, Rhea; Rülicke, Thomas; Georgiev, Oleg; Schaffner, Walter;

Schlagwörter

Animals; Cadmium/pharmacokinetics; Cadmium/toxicity; Coculture Techniques; DNA, Complementary/genetics; DNA-Binding Proteins; Female; Gene Targeting; Hematopoiesis, Extramedullary/physiology*; Hepatocytes/metabolism; Hepatocytes/transplantation; Leukopenia/genetics; Liver/embryology; Liver/growth & development; Liver/metabolism*; Liver/ultrastructure; Male; Metabolic Detoxication, Drug*; Metals, Heavy/pharmacokinetics*; Metals, Heavy/toxicity; Mice; Mice, Knockout; Mice, Transgenic; Organ Specificity; Phenotype; Radiation Chimera; Recombinant Fusion Proteins/physiology; Specific Pathogen-Free Organisms; Transcription Factors/deficiency; Transcription Factors/genetics; Transcription Factors/physiology*; Zinc/pharmacokinetics; Zinc/toxicity;

ISSN/eISSN

0892-6638 -

WoS ID

WOS:000222979200034