Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease.

Autor:in

Meier, Philipp; Genoud, Nicolas; Prinz, Marco; Maissen, Manuela; Rülicke, Thomas; Zurbriggen, Andreas; Raeber, Alex J; Aguzzi, Adriano;

Schlagwörter

Animals; Brain/drug effects; Brain/metabolism; Brain/physiopathology; Disease Models, Animal; Drug Resistance/physiology; Endopeptidases/metabolism; Ligands; Membrane Microdomains/drug effects; Membrane Microdomains/metabolism; Mice; Mice, Transgenic; Molecular Structure; PrPC Proteins/genetics; PrPC Proteins/metabolism*; PrPC Proteins/therapeutic use; PrPSc Proteins/antagonists & inhibitors; PrPSc Proteins/metabolism*; Precipitin Tests; Prion Diseases/drug therapy; Prion Diseases/genetics; Prion Diseases/metabolism*; Prions/antagonists & inhibitors; Prions/metabolism*; Prions/pathogenicity; Protein Isoforms/drug effects; Protein Isoforms/genetics; Protein Isoforms/metabolism; Receptors, IgG/genetics; Receptors, IgG/metabolism*; Receptors, IgG/therapeutic use; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism*; Recombinant Fusion Proteins/therapeutic use; Scrapie/drug therapy; Scrapie/genetics; Scrapie/metabolism;

ISSN/eISSN

0092-8674 -

WoS ID

WOS:000182282900006