IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Müller, Mathias

Schlagwörter

Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport/deficiency; Animals; Antigens, Differentiation; Cells, Cultured; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology*; Gene Expression Regulation/immunology*; Humans; Interferon Regulatory Factor-3; Interferon-alpha/biosynthesis; Interferon-alpha/physiology; Interferon-beta/biosynthesis*; Interferon-beta/deficiency; Interferon-beta/genetics; Interferon-beta/physiology; Intracellular Fluid/immunology*; Intracellular Fluid/metabolism; Intracellular Fluid/microbiology*; Intracellular Signaling Peptides and Proteins/deficiency; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/physiology*; Listeria monocytogenes/immunology; Macrophages/immunology; Macrophages/metabolism; Macrophages/microbiology; Membrane Glycoproteins/deficiency; Membrane Glycoproteins/genetics; Membrane Glycoproteins/physiology*; Membrane Proteins/deficiency; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Nod2 Signaling Adaptor Protein; Protein Isoforms/biosynthesis; Protein Isoforms/physiology; Receptors, Cell Surface/deficiency; Receptors, Cell Surface/genetics; Receptors, Cell Surface/physiology*; Receptors, Immunologic/deficiency; Signal Transduction/genetics; Signal Transduction/immunology; Toll-Like Receptors; Transcription Factors/deficiency; Transcription Factors/genetics; Transcription Factors/physiology*;

ISSN/eISSN

0022-1767 -

WoS ID

WOS:000225665100039

URL

http://www.jimmunol.org/content/173/12/7416