First Detection of GES-5-Producing Escherichia coli from Livestock-An Increasing Diversity of Carbapenemases Recognized from German Pig Production

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Käsbohrer, Annemarie

Abstrakt

Resistance to carbapenems due to carbapenemase-producing Enterobacteriaceae (CPE) is an increasing threat to human health worldwide. In recent years, CPE could be found only sporadically from livestock, but concern rose that livestock might become a reservoir for CPE. In 2019, the first GES carbapenemase-producing Escherichia coli from livestock was detected within the German national monitoring on antimicrobial resistance. The isolate was obtained from pig feces and was phenotypically resistant to meropenem and ertapenem. The isolate harbored three successive bla(GES) genes encoding for GES-1, GES-5 and GES-5B in an incomplete class-I integron on a 12 kb plasmid (pEC19-AB02908; Acc. No. MT955355). The strain further encoded for virulence-associated genes typical for uropathogenic E. coli, which might hint at an increased pathogenic potential. The isolate produced the third carbapenemase detected from German livestock. The finding underlines the importance CPE monitoring and detailed characterization of new isolates.

Dokumententyp

Originalarbeit

Open Access Type

Gold

WoS ID

WOS:000587405200001