Zeitschriftenaufsatz | 2003

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock.

Autor:in

Karaghiosoff, Marina; Steinborn, Ralf; Kovarik, Pavel; Kriegshäuser, Gernot; Baccarini, Manuela; Donabauer, Birgit; Reichart, Ursula; Kolbe, Thomas; Bogdan, Christian; Leanderson, Tomas; Levy, David; Decker, Thomas; Müller, Mathias;

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Karaghiosoff, Marina; Müller, Mathias; Steinborn, Ralf; Reichart, Ursula; Kolbe, Thomas

Journal

Nature Immunology

Schlagwörter

Animals; Cytokines/biosynthesis; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Female; Gene Expression; Interferon Regulatory Factor-1; Interferon Regulatory Factor-7; Interferon Type I/genetics*; Interferon-alpha/genetics; Interferon-beta/genetics; Lipopolysaccharides/toxicity; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide/biosynthesis; Phosphoproteins/genetics; Protein-Tyrosine Kinases/deficiency; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism*; Proteins/genetics; Proteins/metabolism*; RNA, Messenger/genetics; RNA, Messenger/metabolism; STAT1 Transcription Factor; Shock, Septic/etiology; Shock, Septic/genetics; Shock, Septic/immunology*; TYK2 Kinase; Trans-Activators/deficiency; Trans-Activators/genetics; Trans-Activators/metabolism;

Dokumententyp

Originalarbeit

ISSN/eISSN

1529-2908 -

DOI

10.1038/ni910

WoS ID

WOS:000182665400015

PubMed ID

12679810