Zeitschriftenaufsatz
|
2015
Prevalence and risk factors of gammaherpesvirus infection in domestic cats in Central Europe
Autor:in
Ertl, R.; Korb, Melanie; Langbein-Detsch, Ines; Klein, D.
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Abstrakt
Background: Gammaherpesviruses (GHVs) are a large group of dsDNA viruses that can infect humans and several animal species. The two human GHVs, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are known for their oncogenic properties in individuals with immunodeficiency. Recently, the first feline GHV, Felis catus gammaherpesvirus 1 (FcaGHV1) was discovered and frequently found in domestic cats in Australia, Singapore and the USA. FcaGHV1 is more likely to be detected in cats co-infected with the feline immunodeficiency virus (FIV).
Findings: The prevalence of FcaGHV1 in pet cats from Germany and Austria was 16.2 % (95 % CI = 12.38-20.02). The odds for GHV infection were greater for FIV positive (OR = 4.5), male (OR = 13.32) and older (OR = 2.36) cats. Furthermore, FcaGHV1 viral loads were significantly higher in FIV-infected cats compared to matched controls.
Conclusions: GHV infections are common in domestic cats in Central Europe. The worldwide distribution of FcaGHV1 can be assumed. A potential role as a co-factor in FIV-induced pathogeneses is supported.
Schlagwörter
Animals; Austria/epidemiology; Cat Diseases/epidemiology*; Cat Diseases/virology; Cats; Feline Acquired Immunodeficiency Syndrome/complications; Female; Gammaherpesvirinae/isolation & purification*; Germany/epidemiology; Herpesviridae Infections/epidemiology; Herpesviridae Infections/veterinary*; Male; Molecular Sequence Data; Prevalence; Risk Factors; Sequence Analysis, DNA; Viral Load;
Dokumententyp
Originalarbeit
CC Lizenz
CCBY
Open Access Type
Gold
ISSN/eISSN
1743-422X -
10.1186/s12985-015-0381-6
WoS ID
PubMed ID