BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

Autor:in

Hilberg, Frank; Roth, Gerald J; Krssak, Martin; Kautschitsch, Susanna; Sommergruber, Wolfgang; Tontsch-Grunt, Ulrike; Garin-Chesa, Pilar; Bader, Gerd; Zoephel, Andreas; Quant, Jens; Heckel, Armin; Rettig, Wolfgang J;

Schlagwörter

Animals; Apoptosis/drug effects; Blood Coagulation Factors/antagonists & inhibitors*; Cell Proliferation/drug effects; Cells, Cultured; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacokinetics; Enzyme Inhibitors/therapeutic use*; Female; Humans; Indoles/chemical synthesis; Indoles/pharmacokinetics; Indoles/therapeutic use*; Mice; Mice, Nude; Molecular Structure; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/metabolism; Neoplasms, Experimental/drug therapy*; Neoplasms, Experimental/metabolism; Neoplasms, Experimental/pathology; Pericytes/cytology; Pericytes/drug effects; Pericytes/metabolism; Rats; Rats, Inbred F344; Receptors, Fibroblast Growth Factor/antagonists & inhibitors*; Receptors, Fibroblast Growth Factor/metabolism; Receptors, Platelet-Derived Growth Factor/antagonists & inhibitors*; Signal Transduction; Tissue Distribution; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors*; Vascular Endothelial Growth Factor Receptor-2/immunology; Vascular Endothelial Growth Factor Receptor-2/metabolism; Xenograft Model Antitumor Assays;

ISSN/eISSN

0008-5472 - 1538-7445

WoS ID

WOS:000256855700036