Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

Autor:in

Kessenbrock, Kai; Fröhlich, Leopold; Sixt, Michael; Lämmermann, Tim; Pfister, Heiko; Bateman, Andrew; Belaaouaj, Azzaq; Ring, Johannes; Ollert, Markus; Fässler, Reinhard; Jenne, Dieter E;

Schlagwörter

Animals; Antigen-Antibody Complex/pharmacology; Arthus Reaction/metabolism; Arthus Reaction/pathology; Arthus Reaction/prevention & control; Cell Movement/drug effects; Chemotaxis, Leukocyte/drug effects; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/pathology*; Intercellular Signaling Peptides and Proteins/metabolism*; Intercellular Signaling Peptides and Proteins/pharmacology; Leukocyte Elastase/genetics; Leukocyte Elastase/metabolism*; Mice; Mice, Inbred Strains; Mice, Knockout; Models, Biological; Myeloblastin/genetics; Myeloblastin/metabolism*; Neutrophil Activation/drug effects; Neutrophils/cytology; Neutrophils/drug effects; Neutrophils/metabolism; Ovalbumin/immunology; Respiratory Burst/drug effects; Tetradecanoylphorbol Acetate/pharmacology;

ISSN/eISSN

0021-9738 -

WoS ID

WOS:000257657400012