Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs.

Autor:in

Aichberger, Karl J; Gleixner, Karoline V; Mirkina, Irina; Cerny-Reiterer, Sabine; Peter, Barbara; Ferenc, Veronika; Kneidinger, Michael; Baumgartner, Christian; Mayerhofer, Matthias; Gruze, Alexander; Pickl, Winfried F; Sillaber, Christian; Valent, Peter;

Schlagwörter

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Apoptosis/physiology; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/metabolism*; Blotting, Northern; Blotting, Western; Boronic Acids/pharmacology; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic*; Genes, Tumor Suppressor; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mast Cells/drug effects; Mast Cells/metabolism*; Mast Cells/pathology; Mastocytosis, Systemic/drug therapy; Mastocytosis, Systemic/genetics; Mastocytosis, Systemic/metabolism*; Membrane Proteins/genetics; Membrane Proteins/metabolism*; Mutation; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism*; Proto-Oncogene Proteins c-kit/genetics*; Pyrazines/pharmacology; RNA, Small Interfering; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine/analogs & derivatives; Staurosporine/pharmacology; Transfection;

ISSN/eISSN

0006-4971 -

WoS ID

WOS:000272863800015

Titel des Sammelwerks

BLOOD;