In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V.

Autor:in

Böhm, Alexandra; Sonneck, Karoline; Gleixner, Karoline V; Schuch, Karina; Pickl, Winfried F; Blatt, Katharina; Peter, Barbara; Herrmann, Harald; Schernthaner, Gerit-Holger; Pehamberger, Hubert; Rabitsch, Werner; Sperr, Wolfgang R; Valent, Peter;

Schlagwörter

Adult; Aged; Amino Acid Substitution; Antineoplastic Agents/administration & dosage*; Apoptosis/drug effects; Apoptosis/genetics; Benzamides; Caspases/metabolism; Cell Line, Tumor; Cladribine/administration & dosage*; Drug Resistance, Neoplasm/drug effects*; Drug Resistance, Neoplasm/genetics; Female; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/genetics; Humans; Male; Mast Cells/enzymology*; Mast Cells/pathology; Mastocytosis, Systemic/drug therapy*; Mastocytosis, Systemic/enzymology*; Mastocytosis, Systemic/genetics; Mastocytosis, Systemic/pathology; Middle Aged; Mutation, Missense*; Piperazines/pharmacology*; Proto-Oncogene Proteins c-kit/genetics; Proto-Oncogene Proteins c-kit/metabolism*; Pyrimidines/pharmacology*; Tryptases/blood;

ISSN/eISSN

0301-472X -

WoS ID

WOS:000281168700004

Titel des Sammelwerks

EXPERIMENTAL HEMATOLOGY;