Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.

Autor:in

Aktas, Orhan; Prozorovski, Timour; Smorodchenko, Alina; Savaskan, Nicolai E; Lauster, Roland; Kloetzel, Peter-Michael; Infante-Duarte, Carmen; Brocke, Stefan; Zipp, Frauke;

Schlagwörter

Administration, Oral; Animals; Catechin/administration & dosage; Catechin/analogs & derivatives*; Catechin/pharmacology*; Cell Death/drug effects; Cell Line; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases/antagonists & inhibitors; Down-Regulation/drug effects; Encephalomyelitis, Autoimmune, Experimental/pathology; Encephalomyelitis, Autoimmune, Experimental/physiopathology; Encephalomyelitis, Autoimmune, Experimental/prevention & control*; Female; Growth Inhibitors/pharmacology; Humans; I-kappa B Proteins/biosynthesis; Immunity, Cellular/drug effects; Jurkat Cells; Mice; NF-kappa B/antagonists & inhibitors*; NF-kappa B/metabolism*; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Neuroprotective Agents/administration & dosage; Neuroprotective Agents/therapeutic use*; Proto-Oncogene Proteins/antagonists & inhibitors; Reactive Oxygen Species/antagonists & inhibitors; Reactive Oxygen Species/metabolism; T-Lymphocytes/drug effects*; T-Lymphocytes/immunology; T-Lymphocytes/metabolism*; Tea*; Up-Regulation/drug effects;

ISSN/eISSN

0022-1767 -

PubMed ID

15494532