Zeitschriftenaufsatz | 2011 Open Access

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.

Autor:in

Blanc, Mathieu; Hsieh, Wei Yuan; Robertson, Kevin A; Watterson, Steven; Shui, Guanghou; Lacaze, Paul; Khondoker, Mizanur; Dickinson, Paul; Sing, Garwin; Rodríguez-Martín, Sara; Phelan, Peter; Forster, Thorsten; Strobl, Birgit; Müller, Matthias; Riemersma, Rudolph; Osborne, Timothy; Wenk, Markus R; Angulo, Ana; Ghazal, Peter;

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Müller, Mathias; Strobl, Birgit

Journal

PLoS Biology

Schlagwörter

Animals; Antiviral Agents/pharmacology; Cholesterol/metabolism; Down-Regulation*; Herpesviridae Infections/immunology*; Herpesviridae Infections/metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Immunity, Innate; Interferon-beta/biosynthesis; Interferon-beta/pharmacology; Interferon-beta/physiology*; Interferon-gamma/biosynthesis; Interferon-gamma/pharmacology; Interferon-gamma/physiology*; Macrophages/immunology; Macrophages/metabolism; Macrophages/virology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muromegalovirus/immunology*; NIH 3T3 Cells; RNA Interference; Signal Transduction; Simvastatin/pharmacology; Sterol Regulatory Element Binding Protein 2/physiology; Sterols/biosynthesis*;

Dokumententyp

Originalarbeit

ISSN/eISSN

1544-9173 -

DOI

10.1371/journal.pbio.1000598

WoS ID

WOS:000288942200003

PubMed ID

21408089

Titel des Sammelwerks

PLOS BIOLOGY;