Zeitschriftenaufsatz | 2004 Open Access

Illuminating the evolutionary history of chlamydiae.

Autor:in

Horn, Matthias; Collingro, Astrid; Schmitz-Esser, Stephan; Beier, Cora L; Purkhold, Ulrike; Fartmann, Berthold; Brandt, Petra; Nyakatura, Gerald J; Droege, Marcus; Frishman, Dmitrij; Rattei, Thomas; Mewes, Hans-Werner; Wagner, Michael;

Journal

Science

Schlagwörter

Acanthamoeba/microbiology; Animals; Bacterial Proteins/analysis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biological Evolution*; Cell Membrane/chemistry; Cell Wall/chemistry; Chlamydia/classification; Chlamydia/genetics; Chlamydia/metabolism; Chlamydia/pathogenicity; Chlamydiales/classification*; Chlamydiales/genetics*; Chlamydiales/metabolism; Chlamydiales/pathogenicity; Chlamydophila/classification; Chlamydophila/genetics; Chlamydophila/metabolism; Chlamydophila/pathogenicity; Electron Transport; Gene Order; Gene Transfer, Horizontal; Genes, Bacterial; Genome, Bacterial*; Molecular Sequence Data; Nucleotide Transport Proteins/metabolism; Phylogeny; Symbiosis; Virulence; Virulence Factors/genetics; Virulence Factors/metabolism;

Dokumententyp

Originalarbeit

ISSN/eISSN

0036-8075 -

DOI

10.1126/science.1096330

WoS ID

WOS:000221105300043

PubMed ID

Weitere Details

Band

304

Startseite

728

letzte Seite

730

Nummer

5671

@enChlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.

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@enChlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.

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