Zeitschriftenaufsatz | 2012

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.

Autor:in

Hantschel, Oliver; Warsch, Wolfgang; Eckelhart, Eva; Kaupe, Ines; Grebien, Florian; Wagner, Kay-Uwe; Superti-Furga, Giulio; Sexl, Veronika;

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Grebien, Florian; Sexl, Veronika

Journal

Nature Chemical Biology

Schlagwörter

Animals; Antineoplastic Agents/pharmacology; Benzamides; Cell Line, Tumor; Fusion Proteins, bcr-abl/antagonists & inhibitors; Fusion Proteins, bcr-abl/metabolism*; HEK293 Cells; Humans; Janus Kinase 2/antagonists & inhibitors; Janus Kinase 2/deficiency; Janus Kinase 2/metabolism*; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism*; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperazines/pharmacology; Pyrimidines/pharmacology; STAT5 Transcription Factor/antagonists & inhibitors; STAT5 Transcription Factor/metabolism*; Signal Transduction*/drug effects; U937 Cells;

Dokumententyp

Originalarbeit

ISSN/eISSN

1552-4450 -

DOI

10.1038/nchembio.775

WoS ID

WOS:000300600000014

PubMed ID

22286129

Titel des Sammelwerks

NATURE CHEMICAL BIOLOGY;