Zeitschriftenaufsatz
|
2012
The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils.
Autor:in
Blatt, Katharina; Herrmann, Harald; Mirkina, Irina; Hadzijusufovic, Emir; Peter, Barbara; Strommer, Sabine; Hoermann, Gregor; Mayerhofer, Matthias; Hoetzenecker, Konrad; Klepetko, Walter; Ghanim, Viviane; Marth, Katharina; Füreder, Thorsten; Wacheck, Volker; Valenta, Rudolf; Valent, Peter;
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Schlagwörter
Adult; Aged; Aged, 80 and over; Animals; Antibody-Dependent Cell Cytotoxicity/drug effects*; Basophils/drug effects*; Basophils/immunology; Cell Line, Tumor; Cell Proliferation/drug effects*; Down-Regulation/drug effects; Female; Humans; Imidazoles/adverse effects; Imidazoles/pharmacology*; Immunoglobulin E/immunology; Immunoglobulin E/metabolism; Immunoglobulin E/pharmacology; Immunoglobulin E/physiology*; Male; Mast Cells/drug effects*; Mast Cells/immunology; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy/adverse effects; Phosphatidylinositol 3-Kinases/antagonists & inhibitors; Quinolines/adverse effects; Quinolines/pharmacology*; TOR Serine-Threonine Kinases/antagonists & inhibitors; Xenograft Model Antitumor Assays;
Dokumententyp
Originalarbeit
ISSN/eISSN
1932-6203 -
10.1371/journal.pone.0029925
WoS ID
PubMed ID
Titel des Sammelwerks
PLOS ONE;