Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.

Autor:in

Kurt, Timothy D; Bett, Cyrus; Fernández-Borges, Natalia; Joshi-Barr, Shivanjali; Hornemann, Simone; Rülicke, Thomas; Castilla, Joaquín; Wüthrich, Kurt; Aguzzi, Adriano; Sigurdson, Christina J;

Schlagwörter

Amino Acid Substitution/genetics*; Animals; Cattle; Cricetinae; Deer; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prion Diseases/genetics*; Prion Diseases/prevention & control; Prion Diseases/transmission*; Prions/genetics*; Protein Structure, Secondary; Sheep; Species Specificity;

Open Access Type

Green

DOI

10.1523/JNEUROSCI.4636-13.2014

PubMed ID

24431459