Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

Autor:in

Shehata, Medhat; Schnabl, Susanne; Demirtas, Dita; Hilgarth, Martin; Hubmann, Rainer; Ponath, Elena; Badrnya, Sigrun; Lehner, Claudia; Hoelbl, Andrea; Duechler, Markus; Gaiger, Alexander; Zielinski, Christoph; Schwarzmeier, Josef D; Jaeger, Ulrich;

Schlagwörter

Apoptosis*; Bone Marrow Cells/metabolism*; Bone Marrow Cells/pathology; Casein Kinase II/metabolism; Cells, Cultured; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism*; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; PTEN Phosphohydrolase/metabolism*; Phosphatidylinositol 3-Kinase/metabolism*; Proto-Oncogene Proteins c-akt/metabolism*; Stromal Cells/metabolism; Stromal Cells/pathology;

ISSN/eISSN

0006-4971 -

WoS ID

WOS:000282645900019