Zeitschriftenaufsatz
|
2016
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System
Autor:in
Lunney, Joan K.; Fang, Ying; Ladinig, Andrea; 陈, 南华; li, yanhua; Rowland, Bob; Gourapura, Renukaradhya
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Abstrakt
This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.
Schlagwörter
PRRSV; porcine reproductive and respiratory syndrome; host immunity; genetic control; fetal infection; vaccine responses
Dokumententyp
Übersichtsarbeit
ISSN/eISSN
2165-8102 -
10.1146/annurev-animal-022114-111025
WoS ID
PubMed ID
Herausgeber:innen (Text wie auf der Veröffentlichung)
Lewin, HA; Roberts, RM
Titel des Sammelwerks
Annual Review of Animal Biosciences