Chronic morphine treatment inhibits opioid receptor desensitization and internalization.

Autor:in

Eisinger, Daniela A; Ammer, Hermann; Schulz, Rüdiger;

Schlagwörter

Animals; Arrestins/genetics; Arrestins/metabolism; Cell Line; Enkephalin, Leucine-2-Alanine/pharmacology; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; GTP-Binding Proteins/metabolism; Humans; Hybrid Cells/cytology; Hybrid Cells/drug effects; Hybrid Cells/metabolism; Ionophores/pharmacology; Kidney/cytology; Kidney/drug effects; Kidney/metabolism; Mice; Mitogen-Activated Protein Kinases/drug effects; Mitogen-Activated Protein Kinases/metabolism; Morphine/pharmacology*; Narcotics/pharmacology; Protein Transport/drug effects; Receptor, Muscarinic M4; Receptors, Cannabinoid; Receptors, Cell Surface/drug effects; Receptors, Cell Surface/metabolism; Receptors, Drug/genetics; Receptors, Drug/metabolism; Receptors, Muscarinic/drug effects; Receptors, Muscarinic/metabolism; Receptors, Opioid/drug effects*; Receptors, Opioid/genetics; Receptors, Opioid/metabolism*; Receptors, Opioid, delta/drug effects; Receptors, Opioid, delta/genetics; Receptors, Opioid, delta/metabolism; Receptors, Opioid, mu/drug effects; Receptors, Opioid, mu/genetics; Receptors, Opioid, mu/metabolism; Time Factors; Transfection;

ISSN/eISSN

0270-6474 -

PubMed ID

12451120