Zeitschriftenaufsatz | 2016 Open Access

Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

Autor:in
Filippone, Claudia; Castel, Guillaume; Murri, Severine; Beaulieux, Frederik; Ermonval, Myriam; Jallet, Corinne; Wise, Emma; Ellis, Richard; Marston, Denise; McElhinney, Lorraine; Fooks, Anthony; Desvars-Larrive, Amelie; Halos, Lenaig; Vourc'h, Gwenael; Marianneau, Philippe; TORDO, Noël
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Desvars, Amelie
Journal
Journal of General Virology
Schlagwörter
Animals; Comoros/epidemiology; Female; Genetic Variation; Hantavirus/classification; Hantavirus/genetics; Hantavirus/isolation & purification*; Hantavirus Infections/epidemiology; Hantavirus Infections/veterinary*; Hantavirus Infections/virology; Male; Phylogeny; Rats*; Rodent Diseases/epidemiology; Rodent Diseases/virology*;
Dokumenten­typ
Originalarbeit
Open Access Type
Green
ISSN/eISSN
0022-1317 - 1465-2099
DOI
Öffnen URL 10.1099/jgv.0.000440
WoS ID
Öffnen URL WOS:000375837800004
PubMed ID
Öffnen URL MEDLINE:26932442

Weitere Details

Band
97
Startseite
1060
Letzte Seite
1065
Seiten­anzahl
6
Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Reunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Reunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases. Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.

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