Zeitschriftenaufsatz
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2018
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
Autor:in
Bouwman, Aniek; Daetwyler, Hans; Chamberlain, Amanda J.; Ponce, Carla Hurtado; Sargolzaei, Mehdi; Schenkel, Flavio; Sahana, Goutam; Govignon-Gion, Armelle; Boitard, Simon; Dolezal, Marlies; Pausch, Hubert; Brondum, Rasmus Froberg; Bowman, P; Thomsen, Benny; Guldbrandtsen, Bernt; Lund, Mogens; Servin, Bertrand; Garrick, Dorian; Reecy, James M.; Vilkki, Johanna H.; Bagnato, Alessandro; Wang, Min; Hoff, J. L.; Schnabel, Robert; Taylor, Jeremy F.; Vinkhuyzen, Anna; Panitz, Frank; Bendixen, Christian; Holm, Lars-Erik; Gredler-Grandl, Birgit; Hoze, C.; Boussaha, Mekki; Sanchez, Marie-Pierre; Rocha, Dominique; Capitan, Aurélien; Tribout, T.; Barbat, Anne; Croiseau, Pascal; Drögemüller, Cord; Jagannathan, Vidhya; Jagt, Christy Vander; Crowley, John; Bieber, Anna; Purfield, Deirdre C.; Berry, Donagh; Emmerling, R.; Goetz, Kay-Uwe; Frischknecht, Mirjam; Russ, Ingolf; Soelkner, Johann; Van Tassell, Curtis; Fries, Ruedi; Stothard, Paul; veerkamp, roel; Boichard, Didier; Erdos, Michael R.; Hayes, Ben
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Abstrakt
Stature is affected by many polymorphisms of small effect in humans(1). In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes(2,3). Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 x 10(-8)) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
Schlagwörter
Animals; Body Heightgenetics; Body Sizegenetics; Cattleclassificationgenetics; Conserved Sequence; Genetic Association Studiesveterinary; Genetic Variation; Genome-Wide Association Studystatistics & numerical dataveterinary; Humans; Mammalsgenetics; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Locigenetics
Dokumententyp
Originalarbeit
ISSN/eISSN
1061-4036 - 1546-1718
10.1038/s41588-018-0056-5
WoS ID
PubMed ID