Zeitschriftenaufsatz | 2019 Open Access

Comparative oncology: The paradigmatic example of canine and human mast cell neoplasms

Autor:in

Willman, Michael; Hadzijusufovic, Emir; Hermine, Olivier; Dacasto, Mauro; Marconato, Laura; Bauer, K.; Peter, Barbara; Gamperl, Susi; Eisenwort, Gregor; Jensen-Jarolim, Erika; Mueller, Mathias; Arock, Michel; Vail, David M.; Valent, Peter

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Hadzijusufovic, Emir; Müller, Mathias; Willmann, Michael; Jensen-Jarolim, Erika

Journal

Veterinary and Comparative Oncology

Abstrakt

In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available, and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumours. Unlike low-grade MC neoplasms, high-grade MC disorders usually have a poor prognosis with short survival. In both species, neoplastic MCs display activating KIT mutations, which are considered to contribute to disease evolution. Therefore, tyrosine kinase inhibitors against KIT have been developed. Unfortunately, clinical responses are unpredictable and often transient, which remains a clinical challenge in both species. Therefore, current efforts focus on the development of new improved treatment strategies. The field of comparative oncology may assist in these efforts and accelerate human and canine research regarding diagnosis, prognostication, and novel therapies. In this article, we review the current status of comparative oncology approaches and perspectives in the field of MC neoplasms.

Schlagwörter

canine mast cell neoplasm; CD25; CD30; KIT mutations; tryptase

Dokumententyp

Übersichtsarbeit

CC Lizenz

CCBY

Open Access Type

Hybrid

ISSN/eISSN

1476-5810 - 1476-5829

DOI

10.1111/vco.12440