Evidence of a reverse side-chain effect of tris(pentafluoroethyl)trifluorophosphate [FAP]-based ionic liquids against pathogenic bacteria

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Mikuni-Mester, Patrick-Julian; Rossmanith, Peter

Abstrakt

Increased interest in ionic liquids (ILs) is due to their designable and tunable unique physicochemical properties, which are utilized for a wide variety of chemical and biotechnological applications. ILs containing the Eris (pentafluoroethyl)trifluorophosphate ([FAP]) anion have been shown to have excellent hydrolytic, electrochemical and thermal stability and have been successfully used in various applications. In the present study the influence of the cation on the toxicity of the [FAP] anion was investigated. Due to the properties of [FAP] ILs, the IL-toxicity of seven cations with [FAP] compared to [CI] was examined by determination of minimum inhibitory (MIC) and minimum bactericidal concentrations (MSC) on six Gram-positive and six Gram-negative clinically relevant bacteria. For the first time, to our knowledge, the results provide evidence for a decrease in toxicity with increasing alkyl side-chain length, indicating that the combination of both ions is responsible for this 'reverse side-chain effect'. These findings could portend development of new non-toxic ILs as green alternatives to conventional organic solvents.

Dokumententyp

Originalarbeit

DOI

10.1016/j.ecoenv.2017.10.059

PubMed ID

MEDLINE:29102907