The murine model for Hantaan virus-induced lethal disease shows two distinct paths in viral evolutionary trajectory with and without ribavirin treatment.

Autor:in

Chung, Dong-Hoon; Västermark, Åke; Camp, Jeremy V; McAllister, Ryan; Remold, Susanna K; Chu, Yong-Kyu; Bruder, Carl; Jonsson, Colleen B;

Schlagwörter

Animals; Animals, Newborn; Antiviral Agents/administration & dosage*; DNA Mutational Analysis; Disease Models, Animal; Evolution, Molecular*; Female; Hantaan virus/genetics*; Hantaan virus/isolation & purification; Hemorrhagic Fever with Renal Syndrome/drug therapy; Hemorrhagic Fever with Renal Syndrome/virology*; Lung/virology; Mice; Mice, Inbred ICR; Mutation Rate; Pregnancy; RNA, Viral/genetics*; Ribavirin/administration & dosage*; Sequence Analysis, DNA; Viral Load;

ISSN/eISSN

0022-538X -

WoS ID

WOS:000325275800007