Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice.

Autor:in

Camp, Jeremy V; Chu, Yong-Kyu; Chung, Dong-Hoon; McAllister, Ryan C; Adcock, Robert S; Gerlach, Rachael L; Wiemken, Timothy L; Peyrani, Paula; Ramirez, Julio A; Summersgill, James T; Jonsson, Colleen B;

Schlagwörter

Adult; Animals; Antibodies, Viral/blood; Antibodies, Viral/immunology; Bronchoalveolar Lavage Fluid/cytology; Bronchoalveolar Lavage Fluid/immunology; Cell Line; Cytokines/metabolism; Female; Genes, Viral; Humans; Immunoglobulin G/blood; Immunoglobulin G/immunology; Influenza A Virus, H1N1 Subtype/isolation & purification; Influenza A Virus, H1N1 Subtype/physiology*; Influenza, Human/immunology; Influenza, Human/virology; Lung/immunology; Lung/metabolism; Lung/virology; Macrophages/immunology; Macrophages/virology; Male; Mice; Middle Aged; Orthomyxoviridae Infections/immunology*; Orthomyxoviridae Infections/mortality; Orthomyxoviridae Infections/virology*; Phenotype*; Principal Component Analysis; Virulence; Virus Replication; Weight Loss;

CC Lizenz

CCBY

ISSN/eISSN

1932-6203 -

WoS ID

WOS:000315159200065