Zeitschriftenaufsatz
|
2015
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Autor:in
Grebien, Florian; Vedadi, Masoud; Getlik, Matthäus; Giambruno, Roberto; Grover, Amit; Avellino, Roberto; Skucha, Anna; Vittori, Sarah; Kuznetsova, Ekaterina; Smil, David; Barsyte-Lovejoy, Dalia; Li, Fengling; Poda, Gennadiy; Schapira, Matthieu; Wu, Hong; Dong, Aiping; Senisterra, Guillermo; Stukalov, Alexey; Huber, Kilian V M; Schönegger, Andreas; Marcellus, Richard; Bilban, Martin; Bock, Christoph; Brown, Peter J; Zuber, Johannes; Bennett, Keiryn L; Al-Awar, Rima; Delwel, Ruud; Nerlov, Claus; Arrowsmith, Cheryl H; Superti-Furga, Giulio;
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Schlagwörter
Amino Acid Sequence; Animals; Antineoplastic Agents/pharmacology*; Biphenyl Compounds/pharmacology*; CCAAT-Enhancer-Binding Proteins/genetics; CCAAT-Enhancer-Binding Proteins/metabolism; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Dihydropyridines/pharmacology*; Gene Expression Regulation, Neoplastic*; Histone-Lysine N-Methyltransferase/antagonists & inhibitors*; Histone-Lysine N-Methyltransferase/genetics; Histone-Lysine N-Methyltransferase/metabolism; Histones/genetics; Histones/metabolism; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/metabolism*; Leukemia, Myeloid, Acute/pathology; Mice; Molecular Docking Simulation; Molecular Sequence Data; Molecular Targeted Therapy; Mutation; Myeloid-Lymphoid Leukemia Protein/antagonists & inhibitors*; Myeloid-Lymphoid Leukemia Protein/genetics; Myeloid-Lymphoid Leukemia Protein/metabolism; Protein Binding; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Structure, Tertiary; Signal Transduction; Small Molecule Libraries/pharmacology*; Tumor Cells, Cultured;
Dokumententyp
Originalarbeit
Open Access Type
Green
ISSN/eISSN
1552-4450 -
10.1038/nchembio.1859
WoS ID
PubMed ID