Zeitschriftenaufsatz | 2020 Open Access

IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Autor:in
Ansotegui, Ignacio J.; Melioli, Giovanni; canonica, giorgio walter; Caraballo, Luis; Villa, E; Ebisawa, Motohiro; Passalacqua, Giovanni; Savi, Eleonora; EBO, Didier; Gomez, Rene Maximiliano; Luengo, Olga; Oppenheimer, John; Jensen-Jarolim, Erika; Fischer, David; Haahtela, Tari; Antila, Martti; Bousquet, Jean; Cardona, Victoria; Chiang, Wen Chin; Demoly, Pascal; DuBuske, Lawrence; Puga, Marta; van Wijk, Roy Gerth; Diaz, Sandra Nora Gonzalez; Gonzalez-Estrada, Alexei; Jares, Edgardo; Kalpaklioglu, Ayse Fusun; Tanno, Luciana; Kowalski, Marek L.; Ledford, Dennis K.; Monge-Ortega, Olga Patricia; Almeida, Mario Morais; Pfaar, Oliver; Poulsen, Lars; Pawankar, Ruby; Renz, Prof. Dr Harald Renz; Romano, Antonino; Rosario, Nelson; Rosenwasser, Lanny; Borges, Mario; Scala, Enrico; Senna, Gianenrico; Sisul, J. C.; Tang, Mimi; Thong, Bernard; Valenta, Richard; Wood, Robert; Zuberbier, Torsten
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Jensen-Jarolim, Erika
Journal
World Allergy Organization Journal
Schlagwörter
IgE; Allergy; In vitro tests; Skin tests; Diagnostic strategies
Dokumenten­typ
Originalarbeit
CC Lizenz
CC-BY-NC-ND
Open Access Type
Gold
ISSN/eISSN
1939-4551 -
DOI
Öffnen URL 10.1016/j.waojou.2019.100080
WoS ID
Öffnen URL WOS:000523267300003
PubMed ID
Öffnen URL MEDLINE:32128023

Weitere Details

Band
13
Nummer
2
Seiten­anzahl
50
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.© 2019 The Authors.

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