Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets.

Autor:in

Erard, F; Garcia-Sanz, J A; Moriggl, R; Wild, M T;

Schlagwörter

Animals; CD8 Antigens/biosynthesis; CD8-Positive T-Lymphocytes/immunology*; CD8-Positive T-Lymphocytes/metabolism; Cells, Cultured; Cytotoxicity, Immunologic; Down-Regulation/immunology; Drug Synergism; Immunosuppressive Agents/pharmacology; Interleukin-4/antagonists & inhibitors; Interleukin-4/physiology*; Lymphocyte Activation/immunology*; Mice; STAT6 Transcription Factor; Signal Transduction/immunology; T-Lymphocyte Subsets/immunology*; T-Lymphocyte Subsets/metabolism; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Regulatory/immunology; Trans-Activators/metabolism; Transforming Growth Factor beta/physiology*;

ISSN/eISSN

0022-1767 -

PubMed ID

9886388