Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.

Autor:in

Gruber, Wolfgang; Peer, Elisabeth; Elmer, Dominik P; Sternberg, Christina; Tesanovic, Suzana; Del Burgo, Pedro; Coni, Sonia; Canettieri, Gianluca; Neureiter, Daniel; Bartz, René; Kohlhof, Hella; Vitt, Daniel; Aberger, Fritz

Schlagwörter

Animals; Apoptosis; Benzamidespharmacology; Carcinogenesisdrug effectsmetabolismpathology; Carcinoma, Basal Celldrug therapymetabolismpathology; Cell Proliferation; Drug Resistance, Neoplasm; Hedgehog Proteinsantagonists & inhibitorsmetabolism; Histone Deacetylaseschemistrymetabolism; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Signal Transduction; Smoothened Receptorantagonists & inhibitorsmetabolism; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1antagonists & inhibitorsmetabolism

ISSN/eISSN

0020-7136 -

WoS ID

WOS:000419362200011