DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.

Autor:in

Gruber, Wolfgang; Hutzinger, Martin; Elmer, Dominik Patrick; Parigger, Thomas; Sternberg, Christina; Cegielkowski, Lukasz; Zaja, Mirko; Leban, Johann; Michel, Susanne; Hamm, Svetlana; Vitt, Daniel; Aberger, Fritz;

Schlagwörter

Animals; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Blotting, Western; Carcinoma, Basal Cell/drug therapy; Carcinoma, Basal Cell/genetics; Carcinoma, Basal Cell/metabolism; Carcinoma, Basal Cell/pathology*; Cell Proliferation/drug effects; Cells, Cultured; Drug Resistance, Neoplasm*; Forkhead Transcription Factors/physiology; Hedgehog Proteins/antagonists & inhibitors; Hedgehog Proteins/genetics; Hedgehog Proteins/metabolism*; Humans; Mice; Mice, Nude; NIH 3T3 Cells; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology*; Protein-Serine-Threonine Kinases/antagonists & inhibitors; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism*; Protein-Tyrosine Kinases/antagonists & inhibitors; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism*; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms/drug therapy; Skin Neoplasms/genetics; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Smoothened Receptor/antagonists & inhibitors; Smoothened Receptor/genetics; Smoothened Receptor/metabolism*; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1/antagonists & inhibitors; Zinc Finger Protein GLI1/genetics; Zinc Finger Protein GLI1/metabolism*;

ISSN/eISSN

1949-2553 -

WoS ID

WOS:000376123100056