JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Trifinopoulos, Jana; Gotthardt-Pötsch, Dagmar; Sexl, Veronika

Abstrakt

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common lymphoid progenitors (CLPs) to NK lineage-restricted progenitors (NKPs). The orchestrated action of multiple cytokines is crucial for NK cell development and maturation. Many of these cytokines such as IL-2, IL-7, IL-12, IL-15, IL-21, IL-27, and interferons (IFNs) signal via the Janus Kinase / Signal Transducer and Activator of Transcription (JAK/STAT) pathway. We here review the current knowledge about these cytokines and the downstream signaling involved in the development and maturation of conventional NK cells and their close relatives, innate lymphoid cells type 1 (ILC1). We further discuss the role of suppressor of cytokine signaling (SOCS) proteins in NK cells and highlight their potential for therapeutic application.

Dokumententyp

Übersichtsarbeit

Open Access Type

Gold

DOI

10.3389/fimmu.2019.02590

PubMed ID

MEDLINE:31781102