Zeitschriftenaufsatz
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2024
Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [18F]FDG-PET/MRI
Autor:in
Zachhuber, Lena; Filip, Thomas; Mozayani, Behrang; Lobsch, Mathilde; Scheiner, S.; Vician, Petra; Stanek, J.; Hacker, Marcus; Helbich, Thomas H.; Wanek, Thomas; Berger, Walter; Kuntner, Claudia
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Abstrakt
Cholangiocarcinoma (CCA) is a type of primary liver cancer originating from the biliary tract epithelium, characterized by limited treatment options for advanced cases and low survival rates. This study aimed to establish an orthotopic mouse model for CCA and monitor tumor growth using PET/MR imaging. Murine CCA cells were implanted into the liver lobe of male C57BL/6J mice. The imaging groups included contrast-enhanced (CE) MR, CE-MR with static [18F]FDG-PET, and dynamic [18F]FDG-PET. Tumor volume and FDG uptake were measured weekly over four weeks. Early tumor formation was visible in CE-MR images, with a gradual increase in volume over time. Dynamic FDG-PET revealed an increase in the metabolic glucose rate (MRGlu) over time. Blood analysis showed pathological changes in liver-related parameters. Lung metastases were observed in nearly all animals after four weeks. The study concludes that PET-MR imaging effectively monitors tumor progression in the CCA mouse model, providing insights into CCA development and potential treatment strategies.
Schlagwörter
cholangiocarcinoma; orthotopic; syngeneic; mouse model; positron emission tomography (PET); magnetic resonance imaging (MRI); 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG)
Dokumententyp
Originalarbeit
CC Lizenz
CCBY
Open Access Type
Gold
10.3390/cancers16142591
WoS ID
PubMed ID
Repository Phaidra