Zeitschriftenaufsatz | 2012 Open Access

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway.

Autor:in

Andrukhova, Olena; Zeitz, Ute; Goetz, Regina; Mohammadi, Moosa; Lanske, Beate; Erben, Reinhold G;

Journal

Bone

Schlagwörter

Animals; Enzyme Activation/drug effects; Epithelial Cells/drug effects; Epithelial Cells/enzymology; Epithelial Cells/pathology; Fibroblast Growth Factors/pharmacology*; Gene Expression Regulation/drug effects; Glucuronidase/genetics; Glucuronidase/metabolism; Humans; Hypophosphatemia, Familial/enzymology*; Hypophosphatemia, Familial/pathology*; Immediate-Early Proteins/genetics; Immediate-Early Proteins/metabolism*; Kidney Tubules, Proximal/drug effects*; Kidney Tubules, Proximal/enzymology*; Kidney Tubules, Proximal/pathology; MAP Kinase Signaling System/drug effects*; Male; Mice; Mice, Inbred C57BL; Models, Biological; Phosphoproteins/metabolism; Phosphorylation/drug effects; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism*; Sodium-Hydrogen Antiporter/metabolism; Sodium-Phosphate Cotransporter Proteins, Type IIa/metabolism;

Dokumententyp

Originalarbeit

ISSN/eISSN

8756-3282 -

DOI

10.1016/j.bone.2012.05.015