Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.

Autor:in

Eiring, A M; Page, B D G; Kraft, I L; Mason, C C; Vellore, N A; Resetca, D; Zabriskie, M S; Zhang, T Y; Khorashad, J S; Engar, A J; Reynolds, K R; Anderson, D J; Senina, A; Pomicter, A D; Arpin, C C; Ahmad, S; Heaton, W L; Tantravahi, S K; Todic, A; Colaguori, R; Moriggl, R; Wilson, D J; Baron, R; O"Hare, T; Gunning, P T; Deininger, M W;

Schlagwörter

Aminosalicylic Acids/chemical synthesis; Aminosalicylic Acids/chemistry; Aminosalicylic Acids/pharmacology*; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Benzamides/pharmacology; Cell Line, Tumor; Dasatinib; Drug Discovery; Drug Resistance, Neoplasm/drug effects; Fusion Proteins, bcr-abl/antagonists & inhibitors; Fusion Proteins, bcr-abl/genetics*; Fusion Proteins, bcr-abl/metabolism; Gene Expression Regulation, Leukemic*; Genes, Reporter; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Leukocytes, Mononuclear/drug effects*; Leukocytes, Mononuclear/metabolism; Leukocytes, Mononuclear/pathology; Luciferases/genetics; Luciferases/metabolism; Molecular Docking Simulation; Neoplastic Stem Cells/drug effects*; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Phosphorylation; Piperazines/pharmacology; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary; Pyrimidines/pharmacology; STAT3 Transcription Factor/antagonists & inhibitors; STAT3 Transcription Factor/chemistry; STAT3 Transcription Factor/genetics*; STAT3 Transcription Factor/metabolism; Signal Transduction; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry; Small Molecule Libraries/pharmacology*; Sulfonamides/chemical synthesis; Sulfonamides/chemistry; Sulfonamides/pharmacology*; Thiazoles/pharmacology;

ISSN/eISSN

0887-6924 -

WoS ID

WOS:000350734300008