Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2.

Autor:in

Duechler, M; Shehata, M; Schwarzmeier, J D; Hoelbl, A; Hilgarth, M; Hubmann, R;

Schlagwörter

Antigens, CD/genetics; Antineoplastic Agents/pharmacology; Apoptosis/drug effects*; Base Sequence; Boronic Acids/pharmacology*; Cell Line, Tumor; DNA Primers; Gene Expression Regulation, Neoplastic/immunology*; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/pathology*; Protease Inhibitors/pharmacology*; Proteasome Inhibitors*; Pyrazines/pharmacology*; RNA, Messenger/drug effects; RNA, Messenger/genetics; Receptor, Notch2; Receptors, Cell Surface/antagonists & inhibitors*; Receptors, IgE/genetics*; Reverse Transcriptase Polymerase Chain Reaction;

ISSN/eISSN

0887-6924 -

WoS ID

WOS:000226501900016