Zeitschriftenaufsatz | 2016 Open Access

Biomedical applications of glycosylphosphatidylinositol-anchored proteins

Autor:in
Heider, Susanne; Dangerfield, John; Metzner, Christoph
Schlagwörter
cancer; human immunodeficiency virus; immunology; lipid rafts; membranes; gene therapy; molecular painting; tumor therapy; viral envelope
Dokumenten­typ
Übersichtsarbeit
CC Lizenz
CC-BY
Open Access Type
Hybrid
ISSN/eISSN
0022-2275 - 1539-7262
DOI
Öffnen URL 10.1194/jlr.R070201
WoS ID
Öffnen URL WOS:000387231600005
PubMed ID
Öffnen URL MEDLINE:27542385
Pro­jekt
Gezielte moduläre Transduktion mit retroviralen Vektoren; Untersuchungen zur Plastizität viraler Hüllproteome

Weitere Details

Band
57
Startseite
1778
Letzte Seite
1788
Nummer
10
Seiten­anzahl
11
Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) use a unique posttranslational modification to link proteins to lipid bilayer membranes. The anchoring structure consists of both a lipid and carbohydrate portion and is highly conserved in eukaryotic organisms regarding its basic characteristics, yet highly variable in its molecular details. The strong membrane targeting property has made the anchors an interesting tool for biotechnological modification of lipid membrane-covered entities from cells through extracellular vesicles to enveloped virus particles. In this review, we will take a closer look at the mechanisms and fields of application for GPI-APs in lipid bilayer membrane engineering and discuss their advantages and disadvantages for biomedicine.

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