Zeitschriftenaufsatz
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2021
A STAT5B-CD9 axis determines self-renewal in and leukemic stem cells
Autor:in
Kollmann, Sebastian; Grausenburger, Reinhard; Klampfl, Thorsten; Prchal-Murphy, Michaela; Bastl, Klavdija; Pisa, Hanja; Knab, Vanessa M.; Brandstoetter, Tania; Doma, Eszter; Sperr, Wolfgang R.; Lagger, Sabine; Farlik, Matthias; Moriggl, Richard; Valent, Peter; Halbritter, Florian; Kollmann, Karoline; heller, gerwin; Maurer, Barbara; Sexl, Veronika
Publikationen als Autor:in / Herausgeber:in der Vetmeduni
Journal
Abstrakt
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia, and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.
Schlagwörter
Animals; Cell Self Renewal; Hematopoiesis; Hematopoietic Stem Cellscytologymetabolismpathology; Humans; Leukemiametabolismpathology; Mice; Mice, Inbred C57BL; Neoplastic Stem Cellscytologymetabolismpathology; STAT5 Transcription Factormetabolism; Signal Transduction; Tetraspanin 29metabolism; Tumor Cells, Cultured
Dokumententyp
Originalarbeit
ISSN/eISSN
0006-4971 - 1528-0020
10.1182/blood.2021010980
WoS ID
PubMed ID