Baseline JAK-STAT signaling maintains immune cell homeostasis

Publikationen als Autor:in / Herausgeber:in der Vetmeduni

Müller, Mathias

Abstrakt

Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK-STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK-STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.

Dokumententyp

Originalarbeit

DOI

10.1038/s41590-024-01805-0

PubMed ID

MEDLINE:38684923